Multiple Sclerosis (MS) is a chronic inflammatory, autoimmune, and neurodegenerative disease of the central nervous system (CNS). MS affects approximately 2.5 million people worldwide. High prevalence of MS is seen in northern parts of Europe and North America. Multiple sclerosis (MS) is a potentially disabling disease of the brain and spinal cord (central nervous system). […]
Mesenchymal stem cells (MSCs) therapy is showing potential therapeutic effects on liver function improvement in patients with chronic liver disease and acute chronic liver disease (ACLD). These diseases are mainly caused by alcoholic cirrhosis , high fat blood levels, autoimmune disease or a viral infection, among others. Clinical studies have found that allogeneic BM-MSCs are […]
Posttraumatic stress disorder (PTSD) is a syndrome resulting from exposure to real or threatened serious injury or sexual assault. The signs and symptoms of PTSD appear to arise from complex interactions of psychological and neurobiological factors. Studies have found alterations in the amygdala, prefrontal cortex, hippocampus, and anterior cingulate, and corpus callosum as well as […]
The lung is a highly complex organ; it is responsible for respiration but it also acts as a barrier to exterior pathogens and pollutants. It’s composed of over forty different cell types that make up the three major pulmonary regions: tracheobronchial, intralobar airway, and alveolar. The adult lung is a highly quiescent organ; however, after […]
Tendons are connective tissue that tether our muscles to our bones. They improve our stability and facilitate the transfer of force that allows us to move. But they are also particularly susceptible to injury and damage. Unfortunately, once tendons are injured, they rarely fully recover, which can result in limited mobility and require long-term pain […]
Engineered tissue containing human stem cells has allowed paraplegic rats to walk independently and regain sensory perception. The implanted rats also show some degree of healing in their spinal cords. The research, published in Frontiers in Neuroscience, demonstrates the great potential of stem cells — undifferentiated cells that can develop into numerous different types of […]
Pulmonary arterial hypertension (PAH) is a devastating disease that is caused by a progressive increase in pulmonary vascular resistance, largely because of severe remodeling of distal lung arterioles. By definition, pulmonary hypertension refers to the condition in which resting mean pulmonary arterial pressure (mPAP) is greater than 25 mmHg. Etiology The strict definition of PAH […]
Brachial plexus injury (BPI) is an advanced peripheral nerve injury that results in paralysis of the upper extremities. This injury is often caused by high-energy trauma such as road traffic accidents and young adult groups often experience it. Massive motor neuron damage and impairment functions of the brachial plexus-innervated muscles are the results of severe […]
Age-related macular degeneration (AMD or ARMD) is the most common cause of irreversible vision loss in the developed world. AMD is associated with the presence of drusen, without visual loss early in the disease. However, the disease often slowly progresses over years to retinal atrophy and central retinal degeneration with associated loss of central vision. […]
Even after the approval of multiple new drugs for ulcerative colitis (UC), up to 30% of UC patients still require major abdominopelvic surgery to remove the colon and rectum for medically refractory disease. That is why the development of new and better treatment strategies has been under investigation. The use of mesenchymal stem cells (MSCs) […]